Figure 1 | Modern Pathology

Figure 1

From: Low D2-40 immunoreactivity correlates with lymphatic invasion and nodal metastasis in early-stage squamous cell carcinoma of the uterine cervix

Figure 1

(a) In benign cervical squamous epithelium, D2-40 immunoreactivity is strictly localized to the basal cell layer. Note the lack of immunostaining in the cervical stroma. (b) Strong D2-40 immunostaining in the basal portion of squamous cell carcinoma in situ. The stroma underlying the in situ carcinoma shows moderate immunoreactivity. Invasive squamous cell carcinomas showed three immunostaining patterns: lack of reactivity (c), focal staining usually present at the edge infiltrating tumor nests (d) or diffuse reactivity (e) (immunohistochemical stains for D2-40 with hematoxylin counterstain, original magnification × 100). (f) D2-40 immunoreactivity in benign cervical squamous epithelia, carcinoma in situ and invasive squamous cell carcinomas. Lines indicate median immunostaining score values. All: all invasive tumors; low: invasive tumors showing low D2-40 immunoreactivity; high: invasive tumors showing high D2-40 immunoreactivity. **P<0.01; ***P<0.001 (Kruskal–Wallis test).

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