Table 2 Distribution of high-risk HPV types in different grades of CIN in adolescent cervical biopsies

From: Human papillomavirus genotyping and p16INK4a expression in cervical intraepithelial neoplasia of adolescents

CIN grade

Cases n

High-risk HPV types

  

16

18

31

33

35

45

52

58

Unknown

Total a

CIN 1

45

4 (9%)

1 (2%)

3 (7%)

0

1 (2%)

1 (2%)

6 (13%)

5 (11%)

3 (7%)

18 (40%)

CIN 2

46

18 (39%)

5 (11%)

5 (11%)

0

2 (4%)

1 (2%)

4 (9%)

2 (4%)

0

33 (72%)

CIN 3

51

21 (41%)

7 (14%)

8 (16%)

1 (2%)

1 (2%)

1 (2%)

4 (8%)

4 (8%)

1 (2%)

38 (75%)

  1. Abbreviations: HPV, human papillomavirus; CIN, cervical intraepithelial neoplasia.
  2. The positivity of combined high-risk HPV types between CIN 1 and CIN 2/3 were significantly different (P<0.001).
  3. aCoinfection was observed in five cases of CIN 1, four cases of CIN 2, 10 cases of CIN 3.
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