Figure 2 | Modern Pathology

Figure 2

From: Diffuse large B-cell lymphoma with distinctive patterns of splenic and bone marrow involvement: clinicopathologic features of two cases

Figure 2

Spleen pathology: (a and b) Spleen H&E-stained sections showing diffuse infiltration of the splenic red pulp by large B-cell lymphoma, which is most evident within the cords but is also present in the sinusoids (a, Patient 1, × 200; b, Patient 2, × 600 oil). (c) CD20 immunoperoxidase staining highlights the presence of large B-cell lymphoma in the splenic cords and sinusoids (Patient 2, × 200). (d) Factor VIII immunoperoxidase staining of the spleen illustrates distention of vascular structures by neoplastic cells (Patient 1, × 400 oil).

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