Table 2 Summary of FISH results

Diagnosis	Total specimens	Specimens with successful FISH	Specimens with rearranged 2p23 ALK gene loci	Specimens with extra non-rearranged 2p23 ALK gene loci
Primary systemic ALCL
ALK+	10	6	6	0
ALK−	7	5^a	0	5^a^,^b
Primary cutaneous ALCL	7	7^a	0	5^a^,^b
Diffuse large B-lineage lymphoma, ALK+	1	1	1	0
Diffuse large B-cell lymphoma, ALK−
Anaplastic variant, CD30+	5	5	0	2
Anaplastic variant, CD30−	2	2	0	2
Non-anaplastic	5	5	0	0
Secondary, CD30+	2^c	2^d	0^d	2^e
Follicular lymphoma, grade 1	2	2	0	0
Benign lymph nodes	4	4	0	0
Total	45	39	7	16

^a Include two biopsies from one patient.
^b Virtually identical findings in both biopsies from one patient.
^c Both composite lymphomas at presentation, one with nodular lymphocyte predominant Hodgkin lymphoma and one with follicular lymphoma, grade 1.
^d Also in the primary nodular lymphocyte predominant Hodgkin lymphoma component of one composite case.
^e Rare large cells in nodular lymphocyte predominant Hodgkin lymphoma component also showed extra nonrearranged 2p23 loci.

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