Table 4 Comparison of histologic and immunohistochemical features of mucinous/intestinal-type adenocarcinomas of lunga
Pulmonary intestinal-type adenocarcinoma | Goblet cell mucinous ADCA | Signet ring ADCA | Mucinous variant BAC | Mucinous cystadenocarcinoma | |
|---|---|---|---|---|---|
Histology | Cribriform architecture; ‘dirty necrosis’, stratified columnar cells | Goblet cells floating in pools of mucin | Signet ring cells in pools of mucin | Lepidic, non- invasive growth of goblet cells | Large mucin filled cysts lined by goblet and stratified cells |
Immunohistochemistry | |||||
TTF-1 | + | +/− | + | Usually − | +/− |
CD7 | + | +/− | + | + | NA |
CK20 | − | + | − | + | NA |
MUC1 | + | NA | NA | NA | NA |
MUC2 | +/− | + | − | − | NA |
MUC5AC | +/− | − | + | + | NA |
SPA | NA | +/− | − | − | NA |
CDX-2 | − | + | − | − | NA |
