Table 1 Summary of CDH1 mutation, immunohistochemistry and LOH results
From: E-cadherin alterations in atypical lobular hyperplasia and lobular carcinoma in situ of the breast
Case accrual | Mutation analysis | Immunohistochemistry a | LOH | ||||||
|---|---|---|---|---|---|---|---|---|---|
Case | Lesion | Alteration | Exon | Effect | E-cad | β-cat | α-cat | p120-cat | |
A1 | ALH | None | − | − | − | cyto | No | ||
A2(L1) | ALH | None | − | − | − | cyto | No | ||
A3(L3) | ALH | None | − | − | − | cyto | NR | ||
A4(L5) | ALH | None | − | − | − | cyto | No | ||
A5 | ALH | None | − | − | − | cyto | No | ||
A6 | ALH | None | NR | NR | NR | NR | NR | ||
A7 | ALH | None | + | + | + | + | No | ||
A8 | ALH | None | − | − | − | cyto | No | ||
A9 | ALH | None | − | − | − | cyto | No | ||
A10 | ALH | None | − | − | − | cyto | Yes | ||
A11(L12) | ALH | None | − | − | − | NR | No | ||
A12 | ALH | 2410delC | 15 | Frameshift | − | − | − | cyto | No |
A13 | ALH | None | − | − | − | cyto | No | ||
L1-1(A2) | LCIS | 856G>A | 7 | Ala>Thr | − | − | − | cyto | No |
L1-2(A2) | LCIS | 362A>G | 3 | His>Arg | − | − | − | cyto | Yes |
L2 | LCIS | 274C>T | 3 | His>Tyr | − | − | − | cyto | No |
L3(A3) | LCIS | 2125G>A | 13 | Ala>Thr | − | − | − | cyto | No |
L4 | LCIS | 1323_1333del | 10 | Frameshift | − | − | − | cyto | No |
L5(A4) | LCIS | 1366G>A | 10 | Val>Met | − | − | − | cyto | No |
L6 | LCIS | 1676G>A | 11 | Ser>Asn | − | − | − | cyto | No |
L7 | LCIS | 185G>A | 3 | Gly>Asp | − | − | − | cyto | Yes |
L8 | LCIS | 1309_1310del | 9 | Frameshift | − | − | + | NR | No |
L9 | LCIS | 760G>T | 6 | Asp>Tyr | − | − | NR | cyto | NR |
L10 | LCIS | 989C>T | 7 | Thr>Ile | − | − | − | cyto | No |
L11 | LCIS | 2075C>T | 13 | Ala>Val | NR | NR | NR | NR | No |
L12(A11) | LCIS | 1800A>G | 12 | Ile>Met | − | − | − | NR | No |
A14(L13)b | ALH | None | − | − | NR | NR | No | ||
L13(A14) | LCIS | 1595G>A | 11 | Trp>amber | − | − | NR | NR | No |
P1c | DCIS | None | + | + | + | NR | NR | ||
