Table 3 Summary of results obtained in some of the larger series of fibrolamellar carcinoma (FLM)

Wood et al¹²

5-year survival 45% in resected cases; overall

survival 25 vs 0% in HCC

HCC in noncirrhotic liver not

separately analyzed

Starzl et al¹⁰

12/14 alive (variable follow-up)

5-year follow-up in only 2/12 surviving

patients

Craig et al¹

Overall survival 30%, considered better than

HCC

HCC in noncirrhotic liver not

separately analyzed; four FLM cases in

cirrhotic/fibrotic liver

Berman et al⁵

5-year survival 68%, considered better than HCC

HCC in noncirrhotic liver not

separately analyzed; three cases had

admixed areas of typical HCC

Soreide et al¹¹

All six resected cases alive

None of the cases had 5-year follow-up

Farhi et al⁹

50% overall survival; none in HCC

HCC in noncirrhotic liver not

separately analyzed

Lack et al⁸

Two of three resected cases died; overall 80%

patients died within 3 years; mean survival better

than HCC

HCC in noncirrhotic liver not

separately analyzed

Pinna et al¹⁴

5-year survival 75%

Comparison with same stage HCC not

shown; FLM cases not reviewed and

diagnostic criteria not specified

El Serag and Davila³

5-year survival 32% compared to 7% in HCC

HCC in noncirrhotic liver not

separately analyzed

Nagorney et al¹⁹

Overall survival 31%, better than HCC in

noncirrhotic liver

No difference in survival between FLM

and HCC in noncirrhotic liver among

resected cases

Ringe et al⁶

5-year survival 43% in resected cases; 37% in all

cases

Outcome in FLM similar to HCC

Haas et al²⁰

5-year survival <25% in both FLM and HCC

Outcome in FLM similar to HCC

Katzenstein et al²¹

5-year survival 30%; overall mortality 60%

Outcome in FLM similar to HCC

Present

5-year survival 45%; overall 62% in stage I

disease

Outcome in FLM similar to same-stage

HCC in noncirrhotic liver; better than

HCC in cirrhotic liver