Table 1 MSI, MLH1 loss, and 18q LOH in colorectal carcinoma with signet ring cell and mucinous components and nonmucinous adenocarcinoma

From: Distinct molecular features of colorectal carcinoma with signet ring cell component and colorectal carcinoma with mucinous component

Type of colorectal carcinoma

MSI-H (%)

MLH1 loss (%)

18q LOH present (%)

Carcinoma with signet ring cell component (the signet group)

 ≤19%

7/25 (28%)b1

7/25 (28%)b3

6/20 (30%)d6

 20–49%

2/3 (67%)a1

2/5 (40%)

1/2 (50%)

 ≤49%

9/28 (32%)d1

9/30 (30%)d4

7/22 (32%)b5

 ≥50%

2/8 (25%)

2/7 (29%)

4/7 (57%)

 Any

11/36 (31%)d2

11/37 (30%)d5

11/29 (38%)b6

Carcinoma with mucinous component (the mucinous group)

 ≤19%

11/70 (16%)b2,c

8/61 (13%)

30/54 (56%)

 20–49%

15/44 (34%)b2,f1

11/37 (30%)e1

17/30 (57%)

 ≤49%

26/114 (23%)a2,d3

19/98 (19%)b4

47/84 (56%)

 ≥50%

20/53 (38%)c,a2,f2

14/50 (28%)e2

20/38 (53%)

 Any

46/167 (28%)f3

33/148 (22%)e3

67/122 (55%)

Nonmucinous adenocarcinoma

38/351 (11%)b1,a1,d1,d2,f1,d3,f2,f3

36/352 (10%)b3,d4,d5,e1,b4,e2,e3

194/304 (64%)d6,b5,b6

  1. Superscripts for statistical significance: a1,a2P<0.05; b1–b6P<0.025; c1P<0.01; d1–d6P<0.005; e1–e3P<0.001; f1–f3P<0.0001.
  2. LOH, loss of heterozygosity; MSI-H, microsatellite instability-high.
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