Table 2 A grading system based on the intensity and extent of cytoplasmic and nuclear immunostaining of proteins exhibiting mixed subcellular localization (ie FOXP1 and HIF)

From: Loss of expression and nuclear/cytoplasmic localization of the FOXP1 forkhead transcription factor are common events in early endometrial cancer: relationship with estrogen receptors and HIF-1α expression

Grading

Score

Complete absence of reactivity

Negative (low)

Weak cytoplasmic reactivity (regardless of extent)

Low

Strong cytoplasmic reactivity in less than 50% of tumor cells

Low

Nuclear expression in sporadic tumor cells (<10% of cells)

Low

Strong cytoplasmic expression in more than 50% of tumor cells

High

Nuclear expression in more than 10% of tumor cells

High

Back to article page