Table 1 Distribution of histologic features of study casesa

From: Interobserver agreement and reproducibility in classification of invasive breast carcinoma: an NCI breast cancer family registry study

Histologic feature

Number

%

Registry database (%)

Nottingham grade

   

 I

4

11.4

23

 II

12

34.3

36

 III

19

54.3

41

Nottingham score

   

 <7

10

28.6

84

 ≥7

25

71.4

16

Primary histologic pattern

   

 NSTb

26

74.3

—

 Other

9

25.7

—

Primary or secondary pattern

   

 Any cribriform

0

0

0

 Any tubular

2

5.7

1.8

 Any micropapillary

2

5.7

0.4

 Any mucinous

4

11.4

1.4

 Any lobular

5

14.3

8.5

 Any metaplastic

1

2.9

0.4

 Any medullary

4

11.4

2.8

Lymphatic invasion

   

 Present

6

17.1

—

 Absent

29

82.9

—

Blood vessel invasion

   

 Present

0

0

—

 Absent

35

100

—

Lymphocytic infiltration

   

 Marked

3

8.6

—

 Moderate

4

11.4

—

 Mild

17

48.6

—

 Absent

11

31.4

—

Syncytial growth

   

 Present

3

8.6

—

 Absent

32

91.4

—

Circumscribed margins

   

 Present

7

20

—

 Absent

28

80

—

  1. aBased on reference standard assessment (FOM).
  2. bNST, no special type.
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