Table 3 Accuracy of classification of histologic features in invasive breast cancer relative to reference standard^a

Feature	Category	n^b	Percent cases identified by all reviewers
			Mean	Range
NST	Yes	26	92.0	73.1–100
Any tubular	Yes	2	75.0	0–100
Any micropapillary	Yes	2	62.5	0–100
Any mucinous	Yes	4	95.8	75–100
Any medullary	Yes	4	56.3	0–100
Any metaplastic	Yes	1	41.7	0–100
Any lobular	Yes	5	90.0	80–100
Grade	I	4	83.3	75–100
	II	12	64.6	50–83.3
	III	19	92.5	79–100
Overall score	≥7	25	93.3	84–100
	<7	10	86.7	50–100
Lymphatic invasion	Present	6	65.6	33.3–100
	Absent	29	92.9	48.2–100
Lymphocytic infiltration^c	High	7	92.9	71.4–100
	Low	28	73.7	46.4–92.9
Circumscribed margins	Present	7	67.9	28.6–100
Syncytial growth	Present	3	97.2	66.7–100

^aAccuracy is defined as the percent of the reference standard classifications classified or identified similarly by the reviewing pathologists.
^bNumber of cases according to the reference standard.
^cMarked or moderate vs mild or absent.

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