Table 1 Clinical findings of 14 patients with concurrent t(14;18) and 8q24/c-MYC rearrangement

From: Lymphoid neoplasms associated with concurrent t(14;18) and 8q24/c-MYC translocation generally have a poor prognosis

Case

A/G

BM

CSF

Extramedullary sites

Therapy

Follow-up (mo)

Histology

1

54/F

Small intestine

C

A (7)

DLBCL

2

54/M

Lung, chest wall, testis

C

D (10)

DLBCL

3

64/M

+

+

C

D (81)

DLBCL

4

29/M

+

C

D (5)

BL

5

72/M

+

C

A (11)

BL

6

50/F

+

+

C

D (3)

BL

7

32/M

+

+

Mesenteric LN

C

D (8)

BL

8

67/M

+

−/+

Pelvic LN, small intestine

C

D (9)

BLL

9

61/M

+

−/+

Retroperitoneal LN, colon, prostate

C

D (9)

BLL

10

42/F

+

Small intestine, omentum, breast

C, BMT, RT

D (12)

BLL

11

63/M

+

Testis, lip

C

D (18)

BLL

12

55/M

Ileocecal valve

C

A (5)

BLL

13

58/M

+

Retroperitoneal LN

C, BMT

D (8)

PCM

14

32/F

+

Rituximab

A (7)

Low-grade BCL

  1. BL, Burkitt lymphoma/leukemia; B-like, atypical Burkitt/Burkitt-like lymphoma; DLBCL, diffuse large B-cell lymphoma; BM, bone marrow; BMT, bone marrow transplant; CSF, cerebrospinal fluid; +, neoplastic cells present; −, neoplastic cells not present; −/+, neoplastic cells detected during the disease course; C, chemotherapy; A, alive; D, dead; LN, lymph node; PCM, plasmablastic myeloma; RT, radiotherapy; BCL, B-cell lymphoma.