Figure 16

Eccrine digital papillary adenocarcinoma. The neoplastic columnar epithelia form papillary tufts and buds projecting into the dilated lumina of pre-existing eccrine structures. Due to the degree of cytologic atypia, a tumor with this architectural pattern in the breast would be considered an intermediate-grade cribriform/papillary carcinoma despite the abundant intraluminal necrosis.