Figure 6
From: Basal cell carcinoma: biology, morphology and clinical implications

Nodular BCC: histomorphology. The slit-like retraction with mucin deposition in the adjacent stroma causes the nests of BCC to be only loosely adherent to the collagen. Thus, during processing, the tumor cell nests can drop out of the tissue sample, leaving nothing but an empty space, an important clue to BCC.