Table 1 Statistical significance of relationship between tumor characteristics and aberrant expression of the PI3K pathway proteins
From: The Akt pathway in human breast cancer: a tissue-array-based analysis
Type of cancer | Tumor characteristics | P-value | |||||
|---|---|---|---|---|---|---|---|
PTEN | p-AKT | p-FKHR | p-mTOR | p-S6 | Bcl1 | ||
DCIS | Nuclear grade | 0.006 | NS | NS | NS | 0.01 | NS |
Necrosis | 0.004 | NS | NS | NS | NS | NS | |
Invasive cancer | Tumor grade | 0.038 | NS | NS | 0.01 | 0.04 | 0.05 |
Lymphatic invasion | 0.062 | NS | NS | NS | NS | 0.037 | |
Axillary metastasis | NS | NS | NS | NS | NS | NS | |
ER | NS | NS | NS | NS | NS | 0.001 | |
PR | NS | NS | NS | NS | NS | 0.04 | |
Her-2/neu | NS | NS | NS | NS | NS | 0.057 | |
Ki-67 | 0.04 | NS | NS | NS | NS | NS | |
Recurrence | 0.085 | NS | NS | 0.028 | NS | 0.002 | |
Overall survival | NS | NS | NS | NS | NS | NS | |
