Figure 2
From: Claudin-4 differentiates biliary tract cancers from hepatocellular carcinomas
(a) Claudin-4 membranous immunostaining of the normal biliary epithelium in a large extrahepatic bile duct. (b) Claudin-4-stained normal liver tissue. Low claudin-4 expression in the small bile ductule (arrowhead). (c) Moderately differentiated gallbladder carcinoma. (d) Well-differentiated hepatocellular carcinoma. (e) Intense membranous staining of claudin-4 in common bile duct cancer. (f) Hepatocellular carcinoma shows no claudin-4 expression. Magnification × 150. Inset magnification × 400.
