Table 3 Results of Immunohistochemistry

From: Early-onset gastric cancers have a different molecular expression profile than conventional gastric cancers

Antibodies

Immunohistochemical findings a

Range of staining

 

Age >45 years old

Age <45 years old

All Ages combined

Negative

Positive

E-Cadherin

37% abnormal

52% abnormal

45% positive

NR

NR

β-catenin

23% abnormal

35% abnormal

29% abnormal

NR

NR

p53

48% positive

31% positive

42% positive

0–10%

50–90%

COX-2

66% High

10% High

35% High

NR

NR

TFF

73% negative

39% negative

55% negative

0–1%

25–99%

HuR cytoplasmic

28% positive

13% positive

34% positive

0%

15–100%

HuR nuclear

40% positive

28% positive

34% positive

0%

20–100%

c/ebpβ

80% positive

67% positive

73% positive

0–9%

35–100%

p16

57% negative

34% negative

44% negative

0–5%

20–100%

c-myc

33% positive

52% positive

43% positive

0–5%

6–100%

c-jun

64% positive

74% positive

70% positive

0–5%

6–100%

  1. aTo the nearest percent.
  2. NR, not relevant.