Figure 2 | Modern Pathology

Figure 2

From: Low podoplanin expression in pretreatment biopsy material predicts poor prognosis in advanced-stage squamous cell carcinoma of the uterine cervix treated by primary radiation

Figure 2

(a) Podoplanin immunostaining scores determined in hysterectomy and biopsy materials show a highly significant positive correlation (r=0.8835, P<0.0001, Spearman test). The dotted line represents the calculated regression line. (b) The percent of immunoreactive tumors cells determined in hysterectomy and biopsy materials show a highly significant positive correlation (r=0.8962, P<0.0001, Spearman test). The dotted line represents the calculated regression line. Podoplanin immunoreactivity is significantly lower in cases associated with the presence of lymphatic invasion (c) and nodal metastasis (d), based on both biopsy (•) and hysterectomy (○) material. Bars indicate the median values of podoplanin immunostaining scores (*P<0.05; **P<0.01; ***P<0.001, Mann–Whitney test).

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