Figure 2
From: Spatial and temporal heparanase expression in colon mucosa throughout the adenoma-carcinoma sequence
Heparanase expression in epithelial cells of colon mucosa in the various stages of adenoma–carcinoma sequence, as depicted by anti-heparanase antibody 733. (a) Normal mucosa, distant from the tumor, devoid of heparanase staining (original magnification × 100). (b) Normal mucosa (arrowheads) adjacent to carcinoma, exhibiting supranuclear staining for heparanase (inset 1). Original magnification × 50. (c) Adenoma exhibiting strong, widespread supranuclear staining (inset). Original magnification × 100. (d) A part of an adenoma. Heparanase staining is much more intense in areas with moderate dysplasia (arrowheads), as compared to areas with mild or no dysplasia (arrows). Original magnification × 200. (e) Same as in (d). Heparanase staining intensity in area with severe dysplasia (arrows) is weaker, as compared to an area with moderate dysplasia (arrowheads). Original magnification × 400). (f) Invading carcinoma exhibiting very weak staining in a few isolated cells. Original magnification × 200.
