Table 1 Staining intensities of heparanase during the adenoma–carcinoma transition as revealed by 92.4 and 733 antibodies
From: Spatial and temporal heparanase expression in colon mucosa throughout the adenoma-carcinoma sequence
Histological grade | n | − | ± | + | ++ | +++ | ++++ | |
|---|---|---|---|---|---|---|---|---|
Modified Vienna Classification | Grade of dysplasia or specific anatomic site | |||||||
92.4 Ab expression, n (%) | ||||||||
Category 1 (no neoplasia) | 300 | 176 (58.7) | 70 (23.3) | 42 (14) | 12 (4) | 0 (0.0) | 0 (0.0) | |
Normal (0.5–1 cm from tumor) | 100 | 100 (100) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
Normal (0.2–0.5 cm from tumor) | 100 | 76 (76) | 24 (24) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
Transitional (bordering tumor) | 100 | 0 (0.0) | 47 (47) | 42 (42) | 11 (11) | 0 (0.0) | 0 (0.0) | |
Category 2 (indefinite for neoplasia) | 0 | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
Category 3 (low-grade adenoma/dysplasia) | 121 | 0 (0.0) | 59 (48.8) | 50 (41.3) | 12 (9.9) | 0 (0.0) | 0 (0.0) | |
Mild dysplasia | 67 | 0 (0.0) | 28 (41.8) | 32 (47.8) | 7 (10.4) | 0 (0.0) | 0 (0.0) | |
Moderate dysplasia | 54 | 0 (0.0) | 31 (57.4) | 18 (33.3) | 5 (9.3) | 0 (0.0) | 0 (0.0) | |
Category 4 (high-grade neoplasia) | 177 | 0 (0.0) | 3 (1.7) | 35 (19.8) | 76 (42.9) | 63 (35.6) | 0 (0.0) | |
4.1 High grade | 45 | 0 (0.0) | 3 (6.7) | 17 (37.8) | 25 (55.5) | 0 (0.0) | 0 (0.0) | |
4.2 Noninvasive carcinoma (carcinoma in situ) | 47 | 0 (0.0) | 0 (0.0) | 8 (17) | 17 (36.2) | 22 (46.8) | 0 (0.0) | |
4.3 Suspicion for invasive carcinoma | 31 | 0 (0.0) | 0 (0.0) | 3 (9.7) | 13 (41.9) | 15 (48.4) | 0 (0.0) | |
4.4 Intramucosal carcinoma | 54 | 0 (0.0) | 0 (0.0) | 7 (13) | 21 (38.9) | 26 (48.1) | 0 (0.0) | |
Category 5 Submucosal invasive carcinoma (carcinoma with invasion of the submucosa or deeper) | 265 | 0 (0.0) | 0 (0.0) | 0 (0.0) | 5 (1.9) | 103 (38.9) | 157 (59.2) | |
Invasive carcinoma, superficial layers | 65 | 0 (0.0) | 0 (0.0) | 0 (0.0) | 5 (7.7) | 60 (92.3) | 0 (0.0) | |
Invasive carcinoma, growing edge | 200 | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 43 (21.5) | 157 (78.5) | |
733 Ab expression, n (%) | ||||||||
Category 1 (no neoplasia) | 300 | 134 (44.7) | 75 (25) | 40 (13.3) | 51 (17) | 0 (0.0) | 0 (0.0) | |
Normal (0.5–1 cm from tumor) | 100 | 100 (100) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
Normal (0.2–0.5 cm from tumor) | 100 | 34 (34) | 66 (66) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
Transitional (bordering tumor) | 100 | 0 (0.0) | 9 (9) | 40 (40) | 51 (51) | 0 (0.0) | 0 (0.0) | |
Category 2 (indefinite for neoplasia) | 0 | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
Category 3 (low-grade adenoma/dysplasia) | 249 | 0 (0.0) | 8 (3.2) | 64 (25.7) | 104 (41.8) | 15 (6) | 58 (23.3) | |
Mild dysplasia | 170 | 0 (0.0) | 8 (4.7) | 64 (37.6) | 98 (57.7) | 0 (0.0) | 0 (0.0) | |
Moderate dysplasia | 79 | 0 (0.0) | 0 (0.0) | 0 (0.0) | 6 (7.6) | 15 (19) | 58 (73.4) | |
Category 4 (high-grade neoplasia) | 192 | 123 (67.7) | 69 (35.9) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
4.1 High grade | 65 | 33 (50.8) | 32 (49.2) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
4.2 Noninvasive carcinoma (carcinoma in situ) | 44 | 21 (47.7) | 23 (52.3) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
4.3 Suspicion for invasive carcinoma | 40 | 32 (80) | 8 (20) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
4.4 Intramucosal carcinoma | 43 | 37 (86) | 6 (14) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
Category 5 Submucosal invasive carcinoma (carcinoma with invasion of the submucosa or deeper) | 73 | 63 (86.3) | 10 (13.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
