Figure 1 | Modern Pathology

Figure 1

From: Acquired cystic disease-associated renal tumors: an immunohistochemical and fluorescence in situ hybridization study

Figure 1

Case 1. (a) The tumor was composed of large, eosinophilic cells arranged in a solid pattern with cribriform appearance; (b) numerous oxalate crystals were appreciable within the tumor; (c) immunohistochemistry for AMACR showing strong, granular cytoplasmic staining; (d) immunohistochemistry for CD10 with luminal immunoreactivity, highlighting lumen-like spaces; (e) immunohistochemistry for AE1/AE3 showing membranous immunostaining; (f) immunohistochemistry for CAM5.2 showing membranous immunostaining. FISH analyses with centromeric probes showing nuclei with three hybridization signals for chromosome 1 (g), chromosome 2 (h), and chromosome 6 (i), consistent with chromosomal gains; nuclei with two hybridization signals were observed for chromosome 10 (j) and chromosome 17 (k).

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