Figure 2
Case 2. (a) The tumor was composed mainly of large, eosinophilic cells with a focal component of clear cells, arranged in a solid or acinar architecture, with cribriform appearance; (b) Hale'stain showing a cytoplasmic positive reaction; (c) immunohistochemistry for AMACR displaying strong, granular cytoplasmic staining; (d) immunohistochemistry for CD10 with luminal immunoreactivity, highlighting lumen-like spaces; (e) immunohistochemistry for AE1/AE3 showing membranous immunostaining; (f) immunohistochemistry for vimentin showing cytoplasmic immunostaining. FISH analyses with centromeric probes showing nuclei with three hybridization signals for chromosome 1 (g), chromosome 2 (h), chromosome 6 (i), and chromosome 10 (j), consistent with chromosomal gains; nuclei with two hybridization signals were observed for chromosome 17 (k).
