Table 2 Overall data of the tissues examined

From: Diversity of epidermal growth factor receptor-mediated activation of downstream molecules in human lung carcinomas

Case

Histology

Immunohistochemistry

Immunobltting analysis

FISH a

Mutation

Metastasis

   

EGFR

p-EGFR

p-Stat3

p-Akt

p-Erk

EGFR

p-EGFR

p-Stat3

p-Akt

p-Erk

   

1

ACb

Mixc

2+

1+

1+

7.33 d

4.00

3.15

1.25

0.44

+

 

+

2

SCCe

 

2+

1+

4.86

1.33

4.67

1.38

2.24

+

 

+

3

SCC

 

2+

1+

6.25

1.85

3.15

1.00

0.55

+

  

4

SCC

 

2+

1+

7.00

1.90

2.93

1.14

1.00

+

  

5

AC

Mix

2+

1+

1+

5.60

3.50

3.64

1.00

0.59

+

S695R

 

6

AC

Mix

1+

1.63

5.00

1.25

2.32

2.09

 

del747-753insS

+

7

AC

Mix

1+

1+

1+

2.40

4.10

1.38

4.90

1.00

 

del747-752

+

8

AC

Mix

1+

2.20

2.75

1.09

4.13

1.06

 

L858R

+

9

AC

Mix

1+

1+

1+

3.29

5.00

1.13

3.33

0.65

 

L858R

 

10

SCC

 

2+

1+

2.80

1.90

3.80

1.18

1.20

   

11

SCC

 

2+

1+

4.29

1.57

1.08

1.04

2.23

   

12

AC

Mix

1+

1+

2.25

1.30

2.60

1.25

2.20

   

13

AC

Mix

1+

1+

1.90

1.90

2.40

0

1.60

   

14

AC

Mix

1+

1.60

1.25

2.86

1.31

0.50

   

15

SCC

 

1+

1+

2.60

0

1.17

1.67

0.93

  

+

16

AC

Mix

1+

1+

0

1.25

3.33

1.70

0.50

   

17

AC

Mix

0

0

1.29

1.60

1.50

   

18

AC

Mix

1.70

2.00

2.00

1.29

1.10

   

19

AC

Mix

1+

1.40

0

1.40

3.60

0.50

  

+

20

AC

Mix

1+

1.33

1.22

1.11

1.60

2.70

   

21

AC

Mix

1+

1.20

0

4.25

1.22

0.50

   

22

AC

Papf

1+

1+

1.25

0

2.30

1.20

2.00

   

23

AC

Solidg

1.43

1.10

1.25

1.00

2.50

   

24

SCC

 

1+

1+

1.25

1.00

1.10

1.60

4.30

   

25

SCC

 

1+

1.29

1.43

1.00

2.00

1.50

   

26

SCC

 

1+

1.63

0

1.22

2.00

1.50

   

27

SCC

 

1+

1+

1.11

0

1.30

2.90

3.10

  

+

28

LCh

 

1+

1+

1.00

0

1.82

2.13

1.25

   

Cont1

bulla

 

0.30

0

0.29

0.11

0.90

   

Cont2

bulla

 

0.20

0

0.19

0.15

1.20

   
  1. aFISH, presence of amplification by fluorescein in situ hybridization analysis.
  2. bAC, adenocarcinoma.
  3. cMix, adenocarcinoma of mixed subtype.
  4. dThe cases with values indicated by bold were evaluated as ‘upregulated’ or ‘activated’.
  5. eSCC, squamous cell carcinoma.
  6. fPap, papillary adenocarcinoma.
  7. gSolid, solid adenocracinoma with mucin.
  8. hLC, large cell carcinoma.