Table 3 Clinicopathologic features of phyllodes tumors correlated with 10E4 stromal immunostaining

From: Immunohistochemical expression of heparan sulfate correlates with stromal cell proliferation in breast phyllodes tumors

 

Negative 10E4 stromal staining

Positive 10E4 stromal staining

P-value

Age (mean, in years)

39.53

44.35

a0.0261

Tumor size (mean, in mm)

46.81

62.43

0.0698

Grade

 Benign

114

49

 

 Borderline

21

15

a0.0188

 Malignant

15

18

 

Gross margins

 Well circumscribed

128

64

 

 Poorly circumscribed

5

8

0.1193

 Not available

16

9

 

Cystic degeneration

 Absent

131

66

 

 Present

17

14

0.4088

 Not available

1

1

 

Gross necrosis

 Absent

145

76

 

 Present

3

5

0.2405

 Not available

1

1

 

Gross hemorrhage

 Absent

139

64

 

 Present

9

17

a0.0013

 Not available

0

1

 

Stromal hypercelluarity

 Mild

82

33

 

 Moderate

55

38

0.2006

 Marked

12

10

 

Stromal overgrowth

 Absent

132

63

 

 Present

17

18

a0.0351

Microscopic borders

 Circumscribed

106

45

 

 Focally permeative

39

27

 

 Widely permeative

4

9

a0.0088

Stromal atypia

 Mild

106

54

 

 Moderate

30

21

0.5901

 Marked

13

6

 

Stromal metaplasia

 Absent

145

76

 

 Present

5

4

0.7227

Mitotic activity/10hpf (mean)

4.24

5.561

0.5601

Myxoid change

 Absent

16

12

 

 Present

133

69

0.4016

PASH

 Absent

36

19

 

 Present

113

62

1

Microscopic hemorrhage

 Absent

29

15

 

 Present

120

64

1

Infarction or necrosis

 No infarction or necrosis

119

56

 

 Infarction

27

21

0.2766

 Tumour necrosis

2

3

 

 Both infarction and tumour necrosis

1

1

 

Epithelial hyperplasia

 Absent

44

21

 

 Mild

49

26

0.6456

 Moderate

44

21

 

 Marked

12

10

 

 No epithelium present

2

0

 

Epithelial metaplasia

 Absent

146

77

 

 Present

4

3

0.6966

p53 stromal staining

 Absent

105

45

 

 Present

45

37

a0.0308

bcl2 epithelial staining

 Absent

11

10

 

 Present

139

72

0.237

bcl2 stromal staining

 Absent

10

6

 

 Present

140

76

1

CD117 epithelial staining

 Absent

58

41

 

 Present

91

41

0.1265

CD117 stromal staining

 Absent

146

71

 

 Present

4

11

a0.0034

MIB1epithelial staining

 Absent

77

43

 

 Present

73

39

0.8915

MIB1 stromal staining

 Absent

103

42

 

 Present

47

40

a0.0107

  1. hpf, high power fields; PASH, pseudoangiomatous stromal hyperplasia.
  2. aStatistically significant result.
Back to article page