Figure 1
(a) Immunohistochemical staining for EphA1 shows expression in the epidermis with an accentuation at the outer membrane of the keratinocytes. (b) Immunohistochemistry for EphA2 displays exclusive expression of this receptor tyrosine kinase in the epidermis. (c) Immunohistochemical staining for EphA7 shows expression of this receptor at the basal membrane zone of the epidermis and positive staining of the blood vessels and nerve fibers (not shown) in the dermis. (d) Immunohistochemical staining for EphA1 shows a loss of EphA1 expression in the basal cell carcinoma compared to the normal epidermis. (e) Immunohistochemistry for EphA1 reveals two components in a basal cell carcinoma, a typical basaloid component expressing EphA1 and a more poorly differentiated spindle cell component completely lacking EphA1. (f) Immunohistochemical staining for EphA1 shows EphA1 expression in the normal epidermis, but loss of EphA1 expression in the adjacent squamous cell carcinoma (carcinoma in situ).
