Table 1 Common downregulated genes in hepatocellular carcinoma tumors and cell lines from transcriptional profiling

From: Positional expression profiling indicates candidate genes in deletion hotspots of hepatocellular carcinoma

Cytoband	Accession no.	Name	Symbol	20 Tumors		20 Cell lines
				Median fold reduction	Percentage cases ≥3-fold (%)	Median fold reduction	Percentage cases ≥3-fold (%)
1p13.3	W91952	Vav 3 oncogene	VAV3	3.50	53	3.48	67
1p12	BI918353	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2	HMGCS2	3.59	60	6.89	80
1q42.2	H22747	Angiotensinogen	AGT	4.10	55	9.20	75
2p24.1	BG566740	Apolipoprotein B	APOB	3.59	60	3.24	50
2p22.2	W01373	CCAAT/enhancer binding protein zeta	CEBPZ	4.28	60	3.76	75
3p24.2	W16685	N-glycanase 1	NGLY1	4.01	68	3.15	60
3q21.3	H71112	MCM2 minichromosome maintenance deficient 2	MCM2	4.70	65	5.58	74
3q24–q25.1	H86642	Ceruloplasmin	CP	6.35	75	12.25	95
3q25.1	T83911	Transmembrane 4 superfamily member 4	TM4SF4	3.30	56	3.35	53
3q25.32	W17370	G elongation factor, mitochondrial 1	GFM1	5.08	77	28.71	100
^* 4q13.3	R88884	Vitamin D binding protein	GC	7.37	74	10.15	67
^* 4q31.3	BG616563	Fibrinogen gamma chain	*FGG*	11.79	93	52.54	100
4q32.1	H38897	Tryptophan 2,3-dioxygenase	TDO2	3.06	50	4.56	67
5p13.2	T96003	LMBR1 domain containing 2	LMBRD2	4.91	94	6.63	100
6p21.33	T87339	Apolipoprotein M	APOM	3.11	50	5.12	68
6p12.2	BE796134	Glutathione S-transferase A2	GSTA2	4.00	67	6.36	95
7p15.3	R69654	Oxysterol binding protein-like 3	OSBPL3	7.52	65	3.51	50
7q22.1	R96774	Cytochrome P450, family 3, subfamily A, polypeptide 7	CYP3A7	5.85	56	13.87	92
^* 8p22–p21.3	BG618635	Fibrinogen-like 1	*FGL1*	4.31	53	10.88	80
8q12.1	BM925604	RAB2, member RAS oncogene family	RAB2	3.33	62	3.16	55
10q26.3	T97051	Mitochondrial short-chain enoyl-coenzyme A	ECHS1	3.58	63	3.06	58
11p15.4	H12367	Beta globin	HBB	5.44	74	7.64	93
11p15.1	H45773	Serum amyloid A2	SAA1	3.10	55	3.77	65
12q13.3	R35197	Hydroxysteroid dehydrogenase	RODH	5.02	58	12.31	95
12q21.33	R87181	Decorin	DCN	7.30	75	13.21	77
12q24.13	BM805738	Serine dehydratase	SDS	6.48	69	8.34	90
14q12	N46702	Syntaxin binding protein 6	STXBP6	3.56	64	3.49	57
^* 16q12.2	H57208	Metallothionein 1G	*MT1G*	9.29	75	3.10	60
^* 17p13.3	H69261	Alpha-2-plasmin inhibitor	*SERPINF2*	4.71	55	7.69	90
17q11.2	H29155	Vitronectin	VTN	11.96	75	7.23	78
17q23.2	BM471342	Myotubularin related protein 4	MTMR4	7.17	93	5.45	80
18q12.1	H25541	Ring finger protein 138	RNF138	12.15	68	7.55	95
19q13.33	R08306	Activating transcription factor 5	ATF5	5.21	65	5.36	80
20p12.3	W91932	Proliferating cell nuclear antigen	PCNA	3.34	57	4.09	67
20q11.23	H24115	Transglutaminase 2	TGM2	4.66	70	3.01	53

^*Bold represents candidate genes identified within the common deleted regions of hepatocellular carcinoma.

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Table 1 Common downregulated genes in hepatocellular carcinoma tumors and cell lines from transcriptional profiling

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