Table 2 Validation of candidate genes on hepatocellular carcinoma tumors and cell lines

From: Positional expression profiling indicates candidate genes in deletion hotspots of hepatocellular carcinoma

Chrom. arm

SOR

Genes, symbol

Location

Expression ratio

    

Array (median, quartile)

qRT-PCR a (median, quartile)

4q

4q12–q13

Vitamin D binding protein, GC

4q13.3

0.17 (0.06–0.45)

<0.01 (<0.01–1.06)

 

4q31–q35

Fibrinogen gamma peptide, FGG

4q31.3

0.04 (0.01–0.09)

0.50 (<0.01–3.57)

8p

8p21–p22

Fibrinogen-like 1, FGL1

8p22

0.10 (0.05–0.40)

0.68 (<0.01–14.36)

  

Deleted in liver cancer 1, DLC1b

8p22

0.88 (0.71–1.00)

11.78 (0.83–28.57)

16q

16q12.1–q23.1

Metallothionein 1G, MT1G

16q12.2

0.27 (0.14–0.42)

<0.01 (<0.01–0.02)

  

E-cadherin, CDH1b

16q22.1

1.03 (0.89–1.61)

1.64 (0.17–12.56)

17p

17p13

Alpha-2-plasmin inhibitor, SERPINF2

17p13.3

0.16 (0.10–0.33)

0.10 (<0.01–0.65)

  

Tumor protein p53, TP53b

17p13.1

1.22 (1.04–1.53)

0.01 (<0.01–0.47)

  1. aqRT-PCR validations included 20 cell lines and 12 primary tumors that were subjected to microarray analysis.
  2. bKnown TSG located within region of frequent allelic losses found in HCC.
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