Table 1 Hematoxylin and Eosin features useful in distinguishing benign glands and invasive adenocarcinomaa

From: Pancreatic adenocarcinoma: update on the surgical pathology of carcinomas of ductal origin and PanINs

 

Benign gland

Invasive carcinoma

Haphazard growth pattern

No

Yes

Glands adjacent to vessels

No

Yes

Perineural invasion

No

Yes

Intravascular invasion

No

Yes

Nuclear variation >4 to 1

No

Yes

Intraluminal necrosis

Usually no

Often

Incomplete glands

No

Often

Gland touching fat

No

Yes

  1. aAdapted from Hruban et al7 courtesy of the American Registry of Pathology.
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