Table 2 Immunohistochemical staining in the diagnosis of ductal adenocarcinomaa

From: Pancreatic adenocarcinoma: update on the surgical pathology of carcinomas of ductal origin and PanINs

 

Benign glands (chronic pancreatitis, benign bile duct lesions)

Ductal adenocarinoma

 

(% Abnormal expression)

CEA (monoclonal)b

10

90

B72.3

5

92

p53c

0

60

Smad4 (dpc4)d

0

55

Mesothelin

5

95

  1. aAdapted from Hruban et al7 courtesy of the American Registry of Pathology.
  2. bAbnormal expression is cytoplasmic reactivity.
  3. cAbnormal expression is reactivity in >20% of nuclei.
  4. dAbnormal expression is loss of cytoplasmic and nuclear activity.
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