Table 3 Histologic grading of pancreatic cancer22

From: Pancreatic adenocarcinoma: update on the surgical pathology of carcinomas of ductal origin and PanINs

Tumor grade

Glandular differentiation

Mucin production

Mitoses (per 10 hpf)

Nuclear atypia

1

Well-differentiated duct-like glands

Intensive

≤5

Little pleomorphism, polar arrangement

2

Moderately differentiated duct-like structures and tubular glands

Irregular

6–10

Moderate pleomorphism

3

Poorly differentiated glands, muco-epidermoid and pleomorphic structures

Abortive

>10

Marked pleomorphism and increased nuclear size

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