Figure 9
From: Liver biopsy assessment in chronic viral hepatitis: a personal, practical approach
Small cell change. Small hepatocytes in the center and left of the image have slightly smaller nuclei than normal hepatocytes on the right side, but their cytoplasm is considerably reduced resulting in a markedly increased nuclear to cytoplasmic ratio. Their cytoplasm may also be somewhat basophilic. Trabeculae of hepatocytes with small cell change are often thick or difficult to discern yielding a ‘cobblestone’ appearance. Such cells may form tight subnodules or their clustering may be a little less well defined, as seen here, though they are not found scattered individually the way hepatocytes with large cell change often are (H&E, original magnification × 20).
