Table 1 Clinical characteristics of the 30 patients with transformation from follicular lymphoma to diffuse large B-cell lymphoma

Case no.	Age at diagnosis (yrs)	Sex	Date of diagnosis	Treatment of follicular lymphoma	Time to transformation (m)	Treatment of diffuse large B-cell lymphoma	Follow-up
							Time (m)	Outcome
1	73	M	August 1987	NA	0.5	NA	NA	DoL
2	59	F	February 1987	CHOP, chlorambucil	60	CT	26	DoL
3	50	F	September 1994	—	0	CT	97	CCR
4	62	M	September 1982	RT, chlorambucil	107	CT	18	DoL
5	48	M	August 1989	—	0	MACOP-B, RT	130	DoL
6	50	F	February 1981	WW, RT, alfa-interferon	88	CHOP	7	DoL
7	51	F	October 1987	RT, chlorambucil, Fludara	110	CNOP	5	DoL
8	49	M	November 1997	chorambucil, RT	15	CHOP, RT, ABMT	25	DoL
9	NA	F	NA	NA	NA	NA	NA	NA
10	51	M	February 1986	RT	44	CHOP	129	CCR
11	57	M	May 1988	CHOP	127	CT	57	DoL
12	58	F	December 1981	Chlorambucil, RT	123	CT	98	DoL
13	61	M	July 1983	WW, RT, chlorambucil	61	CHOP	1	DoL
14	62	F	November 1985	—	0	CT	84	DoL
15	49	M	December 1989	Chlorambucil, CT, ABMT	140	CT	NA	DoL
16	37	M	June 1982	RT	93	CHOP, ABMT	26	DoL
17	61	M	September 1990	RT	76	CHOP	3	DoL
18	33	F	November 1992	—	0	CHOP, ABMT	126	CCR
19	71	M	January 1988	WW, chlorambucil	90	CHOP	7	DoL
20	69	F	July 1994	WW	12	CHOP	12	DoL
21	48	F	February 1985	Chlorambucil	60	CHOP	21	DoL
22	25	F	October 1970	RT, chlorambucil	247	CHOP	1	DoL
23	50	F	February 1991	chlorambucil, CHOP	48	MIME	38	DoL
24	57	M	February 1994	Chlorambucil	13	CT, ABMT	123	CCR
25	60	M	October 1997	Chlorambucil	14	CHOP	78	CCR
26	71	F	May 1984	RT	9	COP	4	DoL
27	60	F	January 1987	Splenectomy	3	CHOP	132	DoL
28	51	F	June 1992	CHOP, chlorambucil	58	CT	61	DoL
29	39	F	December 1992	WW, chlorambucil, CHOP	96	MIME	40	DoL
30	46	F	August 1987	WW, chlorambucil	148	CT	73	DoL

ABMT, high dose therapy with autologous stem cell rescue; CCR, continous complete remission; CHOP, cyclofosfamide, vincrisine, adriamycin, and prednisolone; CNOP, cyclofosfamide, vincristine, mitoxantrone, and prednisolone; COP, cyclofosfamide, vincristine, and prednisolone; CT, different combination of chemotherapy; DoL, dead of lymphoma; m, months; MACOP-B, methotrexate, adriamycin, cyclofosfamide, vincrisitne, bleomycin, and prednisolone; MIME, methyl-gag, ifosfamide, methotrexate, and etoposide; NA, not available; RT, radiotherapy; WW, wait and watch; yrs, years.

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