Table 2 Copy number aberrations detected by CGH in FL and transformed DLBCL
From: Genomic imbalances during transformation from follicular lymphoma to diffuse large B-cell lymphoma
Tumor no. | Diagnosis | Bcl-2 (%) | Number | CGH alterations Regions involved |
|---|---|---|---|---|
1 | FLIII | NA | 0 | — |
2 | FLI | 75 | 0 | — |
3 | DLBCL | NA | 0 | — |
4 | DLBCL | NA | 2 | −8p22-pter,−9p23-pter |
5 | DLBCL | NA | 3 | +Xp11.3–q26,−8p22-pter,−9p22-pter |
6 | DLBCL | 0 | 3 | +4,+6pter-q14,+12pter-q22 |
7 | DLBCL | NA | 3 | −5p,+7,−11q22–25 |
8 | DLBCL | 0 | 4 | −4q10–22,−6q14–21,+12pter-q22,+18q |
9 | DLBCL | NA | 6 | −Xpter-q13,+3q26-qter,−4p16,−6q16-qter,+11q13–22,−15 |
10 | DLBCL | NA | 7 | +1q31-qter,−2p23-pter,−4q13–21,−8p12-pter,+11q22–23,+12p11–q21,−18q22-qter |
11 | DLBCL | 100 | 9 | +2p14–16,+2q21–32,−3p14–21,−3q13–22,+6p,+7pter–q22,+8,−18q22–23,+21 |
12:1 | DLBCL | NA | 5 | −X,+1q,−4p,+6p,−6q23-qter |
12:2 | DLBCL | NA | 4 | −X,+1q,+6p,−6q23-qter |
13:1 | DLBCL | 80 | 11 | −1p,−2q33-qter,−4pter-q21,−6p21–q21,+7,+10p12-pter,−10q23-qter,−11q,+12p12–q21,+14q12–21,+21q |
13:2 | DLBCL | 80 | 10 | +X,−1p32-pter,+7,+10p12-pter,−10q23-qter,−11q,+12p12–q21,+14q12–21,+21q,−22q |
14:1 | DLBCL | NA | 8 | +X,−1p21-pter,−6q,+7,−10q22–23,−15q,−16p,−17p |
14:2 | DLBCL | NA | 12 | +X,−1p21-pter,−3q13.1–21,−6q,+7,−10q22–23,−15q,−16p,−17,−18pter-q21,+19p,+21q |
14:3 | DLBCL | NA | 12 | +X,−1p21-pter,−3q13.1–21,−6q,+7,−10q22–23,−15q,−16p,−17,−18pter-q21,+19p,+21q |
15:1 | FLI | 80 | 2 | +X,−9p12–21 |
15:2 | DLBCL | 0 | 5 | +4q31-qter,−9q22,+11q14–22,+13q12–22,+18q12–22 |
16:1 | FLNA | 50 | 0 | — |
16:2 | DLBCL | NA | 8 | +Xq,−1p32-pter,−4q21-qter,−8p,+8q21-qter,+9q22-qter,−15,−17p |
17:1 | FLII | 50 | 2 | +X,+5p |
17:2 | DLBCL | 0 | 4 | +X,+5p,+12q10–21,−16q21–23 |
18:1 | FLI | NA | 0 | — |
18:2 | DLBCL | NA | 9 | +2q22–33,+4q,−6p21,+6q10–21,+8q12–24,+9p,−11q12–13,+12q15–22,+12p12 |
19:1 | FLII | NA | 3 | +12q11–21,−17p,+18pter-q21 |
19:2 | DLBCL | 100 | 4 | −6q15–23,+11,−17p,+18pter-q21 |
20:1 | FLI | 50 | 3 | +12q23–24,+17,+19 |
20:2 | DLBCL | 50 | 3 | +12q23–24,+17,+19 |
21:1 | FLI | 50 | 1 | +1q |
21:2 | DLBCL | 50 | 2 | +1q,+7 |
22:1 | FLI | 90 | 2 | +12q13–15,+18q21 |
22:2 | DLBCL | 75 | 4 | −8p,+12q13–15,+18q21,−19pter-13.2 |
23:1 | FLI | 100 | 1 | +18p |
23:2 | DLBCL | NA | 1 | −4q |
24:1 | FLIII | NA | 3 | +1q23–32,−6q24–26,+18 |
24:2 | DLBCL | NA | 2 | +Xq21-qter,+11p |
25:1 | FLI | NA | 4 | +1q,+11,+18q,+21q |
25:2 | DLBCL | 80 | 4 | +X,+11,+18q,+21q |
26:1 | FLI | NA | 6 | −9p,+9q22-qter,−12p,−13,−17p,+18 |
26:2 | DLBCL | 75 | 7 | −1p21–32,−9p,+9q22-qter,−12p,−13,−17p,−19p |
27:1 | FLI | NA | 0 | — |
27:2 | DLBCL | 25 | 2 | +8p,+8q21.3-qter |
27:3 | DLBCL | NA | 5 | +X,+9pter-31,+15,+18pter-21,+19q13.2-qter |
28:1 | FLI | 90 | 3 | +X,−6q13–15; 22–23 |
28:2 | DLBCL | 100 | 5 | +Xq25-qter,+2p14–16,−6q13–15; 22–23,+7 |
28:3 | DLBCL | 80 | 5 | +X,+2p14–16,−6q13–15; 22–23,+7 |
29:1 | FLI | 50 | 6 | +4,−12q23–24,+13q21–31,−16p,−17,+18 |
29:2 | FLI | 75 | 5 | +4,−12q23–24,+13q21–31,−16p,+18 |
29:3 | FLII | 0 | 5 | +2p13–21,+11p,+15q11–14,−15q15-qter,+19 |
29:4 | DLBCL | 25 | 12 | −X +2p13–21,+3q25-qter,−4q32–33,−6q14–25,+7pter-q31,+8q10–22,+10p,−13q22-qter,+15q11–14,−15q15-qter,−17p, |
30:1 | FLII | NA | 0 | — |
30:2 | FLII | NA | 0 | — |
30:3 | FLII | 80 | 2 | +X,+1q |
30:4 | FLI | NA | 2 | +X,+1q |
30:5 | DLBCL | 50 | 4 | +X,+1q,−6q,+17q |
30:6 | DLBCL | NA | 5 | +X,+1q,−6q,+12,+17q |
