Table 7 Alterations reported as specific for transformed diffuse large B-cell lymphoma
From: Genomic imbalances during transformation from follicular lymphoma to diffuse large B-cell lymphoma
Alteration | Hough et al16 | Goff et al8 | Nagy et al24 | Boonstra et al13 | Present study | Martinez-Climent et al12 |
|---|---|---|---|---|---|---|
+Xq25–26 | 2 (9%) | 0 (0%) | 0 (0%) | 2 (33%) | 4 (25%) | 2 (20%) |
+3q24–25 | 1 (4%) | 0 (0%) | 0 (0%) | 0 (0%) | 1 (6%) | 1 (10%) |
−4q21-qter | 0 (0%) | 1 (17%) | 0 (0%) | 1 (17%) | 3 (19%) | 2 (20%) |
−6q16–21 | 0 (0%) | 0 (0%) | 2 (40%) | 2 (33%) | 3 (19%) | 1 (10%) |
+7pter-q22 | 2 (9%) | 1 (17%) | 0 (0%) | 5 (83%) | 3 (19%) | 1 (10%) |
−8p22-pter | 2 (9%) | 1 (17%) | 0 (0%) | 0 (0%) | 2 (12%) | 0 (0%) |
−9p23-pter | 0 (0%) | 0 (0%) | 1 (20%) | 1 (17%) | 1 (6%) | 0 (0%) |
+11q22 | 0 (0%) | 0 (0%) | 0 (0%) | 1 (17%) | 2 (12%) | 0 (0%) |
+12q15 | 1 (4%) | 1 (17%) | 0 (0%) | 1 (17%) | 3 (19%) | 0 (0%) |
+13q22 | 0 (0%) | 1 (17%) | 0 (0%) | 0 (0%) | 1 (6%) | 0 (0%) |
−17p | 0 (0%) | 1 (17%) | 0 (0%) | 2 (33%) | 1 (6%) | 1 (10%) |
+18q21 | 1 (4%) | 2 (33%) | 2 (40%) | 1 (17%) | 2 (12%) | 2 (20%) |
Cases studied | 23 | 6 | 5 | 6 | 16 | 10 |
Method | CGH | CGH | CGH | CGH | CGH | Array-CGH |
