Table 1 Major categories of liver iron overload
Hereditary hemochromatosis |
HFE-related (Type 1 hereditary hemochromatosis) |
Non-HFE-related (Types 2A, 2B, 3, and 4 hereditary hemochromatosis) |
Hemosiderosis secondary to systemic disease |
Transfusions |
Erythrocyte disorders (hemolysis, ineffective erythropoiesis) |
Anemia of chronic disease |
Cirrhosis-related hemosiderosis |
Miscellaneous hemosiderosis |
Neonatal hemochromatosis |
Hemosiderosis associated with chronic viral or fatty liver disease |
Dietary iron overload |