Figure 6
From: ALK-positive diffuse large B-cell lymphoma: report of four cases and review of the literature
Fluorescence in situ hybridization (FISH) of ALK-DLBCL showing ALK gene rearrangement using the ALK break apart probe from Vysis, Inc. The FISH pattern is positive for a rearrangement involving the ALK gene locus (arrows). The typical abnormal pattern would be expected to show 1R1G1F (one red and one green signal (abnormal) and one fused (yellow) (the remaining normal allele)). In this particular case, the majority of neoplastic cells also demonstrate an additional fused (yellow), signal indicating either a duplication of the ALK gene region or an additional copy of chromosome 2.
