Table 4 Comparison of selected clinical and molecular features from the 33 reported cases of ALK-DLBCL

From: ALK-positive diffuse large B-cell lymphoma: report of four cases and review of the literature

Author, year (reference)

No. of cases

Age

Molecular

  

Ped.

Adult

ALK rearrangement

Technique

Delsol, 19971

7

1

6

ND (3)

RT-PCR for NPM-ALK

Gascoyne, 20032

6a

 

6a

CLTC-ALK

FISH

De Paepe, 20033

3

2

1

CLTC-ALK

FISH

Chikatsu, 20034

1

 

1

CLTC-ALK

RT-PCR

Onciu, 20035

2

2

 

NPM-ALK

RT-PCR

Adam, 20036

1

 

1

NPM-ALK

RT-PCR

McManus, 20047

1

 

1

CLTC-ALK

RT-PCR

Colomo, 20048

1

 

1

NR

 

Ishii, 20059

1

 

1

NRb

 

Rudzski, 200510

2

 

2

Detectedc

FISH

Gesk, 200511

3

3

 

CLTC-ALK

FISH

Isimbaldi, 200612

1

1

 

CLTC-ALK

RT-PCR

Bubala, 200613

1

1

 

CLTC-ALK

FISH

This study

4

 

4

Detected (1/1)

FISH

  1. One of the six cases was initially reported by Delsol et al.1
  2. Only abstract available on Pubmed.
  3. One case reported as consistent with NPM-ALK, abstract only available on Pubmed.
  4. Ped, pediatric; FISH, fluorescence in situ hybridization; RT-PCR, reverse transcriptase-polymerase chain reaction; ND, none detected; NR, not reported; NA, not applicable.
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