Table 6 Associations of number of altered biomarkers status in the primary cancer with clinical and pathologic characteristics of 226 consecutive patients treated with radical cystectomy for urothelial cell carcinoma of the bladder
Number of altered biomarkers in primary cancer (n=226) | ||||||
|---|---|---|---|---|---|---|
None altered | One altered | Two altered | Three altered | Four altered | P | |
Total (%) | 28 (12) | 56 (25) | 59 (26) | 62 (27) | 21 (9) | |
Gender (%) | ||||||
Female | 2 (4) | 11 (24) | 13 (28) | 17 (37) | 3 (7) | |
Male | 26 (14) | 45 (25) | 46 (26) | 45 (25) | 18 (10) | 0.238 |
Pathologic tumor stage (%) | ||||||
pTa, pTis, or pT1 | 12 (29) | 13 (31) | 6 (14) | 9 (21) | 2 (5) | |
pT2 | 14 (22) | 18 (28) | 18 (28) | 12 (19) | 3 (5) | |
pT3 | 2 (2) | 18 (22) | 26 (31) | 27 (33) | 10 (12) | |
pT4 | 0 | 7 (19) | 9 (25) | 14 (39) | 6 (17) | <0.001 |
Pathological grade (%) | ||||||
Grade 1 or 2 | 4 (24) | 6 (35) | 5 (29) | 2 (12) | 0 | |
Grade 3 | 24 (12) | 50 (24) | 54 (26) | 60 (29) | 21 (10) | 0.192 |
Lymph node status (%)a | ||||||
N0 | 28 (18) | 47 (29) | 38 (24) | 36 (23) | 11 (7) | |
N1, N2 | 0 | 9 (14) | 21 (32.3) | 25 (39) | 10 (15) | <0.001 |
Lymphovascular invasion (%)a | ||||||
Negative | 26 (21) | 38 (31) | 24 (19) | 26 (21) | 10 (8) | |
Positive | 2 (2) | 18 (18) | 35 (35) | 35 (35) | 11 (11) | <0.001 |
Concomitant carcinoma in situ (%)a | ||||||
Negative | 21 (16) | 35 (27) | 31 (24) | 31 (24) | 14 (11) | |
Positive | 7 (8) | 21 (23) | 28 (30) | 30 (32) | 7 (8) | 0.169 |
Stage grouping (%)a | ||||||
Organ-confined (<pT3 N0) | 26 (27) | 29 (30) | 21 (22) | 17 (18) | 4 (4) | |
Extra-vesical extension (≥pT3 N0) | 2 (3) | 18 (28) | 17 (27) | 20 (31) | 7 (11) | |
Lymph node metastases (pTany N positive) | 0 | 9 (14) | 21 (32) | 25 (39) | 10 (15) | <0.001 |
