Table 1 Correlation between clinicopathologic factors and presence of a micropapillary pattern in small-size lung adenocarcinoma
Category | No. of patients | Log-rank test (P-value) | Micropapillary pattern | P-value | ||
|---|---|---|---|---|---|---|
Disease-free interval | Overall survival | Negative (n=164) | Positive (n=21) | |||
Age (years) | ||||||
≤65 | 81 | 0.26 | 0.11 | 68 (36.8) | 13 (7.0) | 0.076 |
>65 | 104 | 96 (51.9) | 8 (4.3) | |||
Sex | ||||||
Male | 72 | 0.012 | 0.1 | 63 (34.1) | 9 (4.9) | 0.69 |
Female | 113 | 101 (54.6) | 12 (6.5) | |||
TNM stage | ||||||
IA | 131 | <0.0001 | 0.0002 | 124 (67.0) | 7 (3.8) | 0.0002 |
IB | 7 | 7 (3.7) | 0 (0) | |||
IIA | 15 | 10 (5.4) | 5 (2.7) | |||
IIB | 2 | 1 (0.54) | 1 (0.5) | |||
IIIA | 25 | 19 (10.3) | 6 (3.2) | |||
IIIB | 5 | 3 (1.6) | 2 (1.1) | |||
P-factor | ||||||
P0 | 145 | <0.0001 | 0.0002 | 130 (70.1) | 15 (8.1) | 0.34 |
P1 | 28 | 24 (13.0) | 4 (2.2) | |||
P2 | 10 | 9 (4.9) | 1 (0.5) | |||
P3 | 2 | 1 (0.5) | 1 (0.5) | |||
Tumor size | ||||||
<20 mm | 71 | 0.001 | 0.0065 | 66 (35.7) | 5 (2.7) | 0.144 |
≥20 mm | 114 | 98 (53.0) | 16 (8.7) | |||
Lymph node metastasis | ||||||
<N1 | 159 | <0.0001 | <0.0001 | 144 (78.3) | 15 (8.2) | 0.033 |
≥N2 | 25 | 19 (10.3) | 6 (3.3) | |||
Lymphatic invasion | ||||||
Negative | 117 | <0.0001 | <0.0001 | 111 (61.3) | 6 (3.3) | 0.0002 |
Positive | 64 | 49 (27.1) | 15 (8.3) | |||
Venous invasion | ||||||
Negative | 142 | <0.0001 | <0.0001 | 127 (69.8) | 15 (8.2) | 0.438 |
Positive | 40 | 34 (18.9) | 6 (3.3) | |||
Serum CEA | ||||||
Negative | 136 | <0.0001 | 0.0012 | 122 (69.3) | 16 (9.1) | 0.85 |
Positive | 41 | 34 (19.3) | 4 (2.3) | |||
