Table 1 Clinical, histological, and genetic features of ALK+ ALCL cases
Case | Age | Sex | Histological | ALK | Cytogenetic | ALK | MIB-1 | MIB-1 | CD56 | NPM-ALK a | NPM-ALK | Clinical | B | Outcome/ | Comments |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
no. | (years) | variant | pattern | analysis | fusion partner | index (%) | expression | expression | stage | symptoms | Follow-up (mo) | ||||
1 | 46 | M | Small | C,N | t(2;5) | NPM | 89 | High | Neg | 1.5 | Low | IV | No | AW/36 | |
2 | 3 | F | Common | C,N | NT | NPM | 50 | Low | Neg | 17.2 | High | IV | Yes | DOD/5 | |
3 | 12 | F | Common | C,N | t(2;5) | NPM | 11 | Low | Neg | 6.4 | Low | II | Yes | AW/144 | |
4 | 11 | M | Common | C,N | NT | NPM | 82 | High | Neg | 31.7 | High | IV | Yes | DOD/55 | HS |
5 | 13 | M | Small | C,N | NT | NPM | NA | Low | Pos | 6.6 | Low | II | No | AW/53 | |
6 | 5 | F | Common | C,N | NT | NPM | 88 | High | Neg | 15.5 | High | III | Yes | AW/125 | |
7 | 28 | F | Common | C,N | NT | NPM | 91 | High | Neg | 5.5 | Low | III | No | AW/52 | |
8 | 17 | M | Common | C,N | NT | NPM | 51 | Low | Neg | 3.13 | Low | II | Yes | AW/33 | |
9 | 10 | F | Lymphohistiocytic | C,N | NT | NPM | 36 | Low | Pos | 0.5 | Low | IV | No | AW/3 | |
10 | 9 | F | Common | C,N | NT | NPM | 66 | High | Neg | 5.4 | Low | III | No | AW/18 | |
11 | 20 | M | Common | C,N | NT | NPM | 85 | High | Neg | 4.7 | Low | IV | Yes | AW/6 | auto PBSCT |
12 | 38 | F | Common | C,N | NT | NPM | 79 | High | Neg | 18.3 | High | IV | Yes | DOD/3 | |
13 | 8 | F | Common | C,N | NT | NPM | 76 | High | Pos | 3.8 | Low | III | Yes | AW/31 | |
14 | 1 | F | Small | C,N | t(2;5) | NPM | 62 | Low | Neg | 1.3 | Low | II | No | AW/29 | |
15 | 10 | M | Common | C,N | NT | NPM | 66 | High | Neg | 1 | Low | III | No | AW/26 | |
16 | 5 | M | Lymphohistiocytic | C,N | NT | NPM | 26 | Low | Neg | 1 | Low | III | Yes | AW/10 | |
17 | 3 | M | Common | C,N | NT | NPM | 67 | High | Neg | 2.7 | Low | III | No | AW/5 | |
18 | 11 | F | Common | C,N | NT | NPM | 61 | Low | Neg | 2.2 | Low | III | Yes | AW/9 | |
19 | 2 | M | Common | C,N | NT | NPM | 77 | High | Neg | 2.2 | Low | III | Yes | AW/15 | |
20 | 3 | F | Common | C,N | NT | NPM | 92 | High | Neg | 4.1 | Low | III | No | AW/20 | |
21 | 30 | F | Common | C,N | NT | NPM | 77 | High | Neg | NA | NA | III | Yes | NA | |
22 | 11 | M | Common | C | NT | TPM3 | 72 | High | Neg | NT | NT | I | No | AW/13 | |
23 | 22 | M | Common | C | t(1;2) | TPM3 | 57 | Low | Neg | NT | NT | III | No | AW/24 | |
24 | 40 | M | Lymphohistiocytic | C | NT | TPM3 | 67 | High | Neg | NT | NT | II | No | AW/56 | |
25 | 3 | F | Common | C | t(2;3) | TFG | 39 | Low | Neg | NT | NT | NA | NA | NA | |
26 | 28 | M | Common | C | NT | ATICa | 61 | Low | Neg | NT | NT | III | Yes | AW/42 |
