Table 2 Steroid hormone receptors, cytokeratins, and adhesion molecules in primary breast cancer with known involvement of the brain and CNS metastases from breast cancer
From: Predominance of the basal type and HER-2/neu type in brain metastasis from breast cancer
Primary breast cancer (n=44)a | CNS metastases (n=85)a | |||
|---|---|---|---|---|
Positive (%) | Negative (%) | Positive (%) | Negative (%) | |
Receptors | ||||
ER | 14 (32) | 30 (68) | 29 (34) | 56 (66) |
PR | 11 (25) | 33 (75) | 15 (18) | 70 (82) |
Her-2/neu | 14 (32) | 30 (68) | 29 (34) | 56 (66) |
EGFR | 7 (16) | 37 (84) | 35 (41) | 50 (59) |
Cytokeratins | ||||
CK 5/14 | 13 (30) | 31 (70) | 22 (26) | 61 (74) |
CK 18 | 29 (67) | 14 (32) | 82 (98) | 2 (2) |
CK 19 | 43 (100) | 0 | 80 (96) | 3 (4) |
Adhesion molecules | ||||
E-cadherin | 35 (83) | 7 (17) | 76 (90) | 8 (10) |
β-Catenin | 37 (86) | 6 (14) | 64 (76) | 20 (34) |
