Table 3 Expression of markers of proliferation and apoptosis in primary breast cancer with known involvement of the brain and CNS metastases from breast cancer
From: Predominance of the basal type and HER-2/neu type in brain metastasis from breast cancer
Marker (threshold) | Primary/metastases | Primary/metastases | Primary/metastases |
|---|---|---|---|
Mean | Median | Above threshold | |
Proliferation | |||
Ki 67 (>25%) | 24.9/30.0 | 25/25 | 22 (50%)/47 (55%) |
Skp 2 (>10%) | 6/13.4 | 2.5/2.5 | 4 (10%)/27 (32%) |
p27 (>50%) | 47/49.2 | 45/55 | 21 (48%)/46 (54%) |
Cyclin D1 (>10%) | 17.7/19.7 | 2.5/7.5 | 17 (39%)/41 (48%) |
Cyclin D3 (>10%) | 29.8/17.7 | 15/7.5 | 26 (59%)/34 (40%) |
Apoptosis | |||
bcl 6 (>10%) | 14.7/22.4 | 2.5/7.5 | 12 (27%)/38 (45%) |
bcl 2 (>30%) | 25.8/23.5 | 2.5/2.5 | 21 (48%)/24 (28%) |
