Table 5 Expression of markers of proliferation and apoptosis in paired samples from primary breast cancer and CNS metastases
From: Predominance of the basal type and HER-2/neu type in brain metastasis from breast cancer
Marker (threshold) | Primary/metastasis | Primary/metastasis | Primary/metastasis |
|---|---|---|---|
Mean | Median | Above threshold | |
Proliferation | |||
Ki-67 (>25%) | 25.7/26.5 | 15.0/30.0 | 10 (44%)/11 (48%) |
Skp 2 (>10%) | 3.0/9.5 | 2.5/2.5 | 1 (5%)/6 (28%) |
p27 (>50%) | 57.3/58.7 | 60.0/65.0 | 14 (61%)/15 (65%) |
Cyclin D1 (>10%) | 19.4/28.2 | 2.5/25.0 | 9 (39%)/15 (65%) |
Cyclin D3 (>10%) | 46.9/24.6 | 45.0/15.0 | 18 (78%)/15 (65%) |
Apoptosis | |||
bcl 6 (>30%) | 25.8/12.6 | 11.3/7.5 | 10 (43%)/8 (35%) |
bcl 2 (>10%) | 28.6/29.5 | 15.0/2.5 | 15 (65%)/8 (35%) |
