Table 6 Changes of marker expression in paired samples from primary breast cancer and CNS metastases (n=23)a
From: Predominance of the basal type and HER-2/neu type in brain metastasis from breast cancer
Primary/metastasis | Constant | +/+ | −/− | Gain | Loss |
|---|---|---|---|---|---|
ER | 17 (74%) | 7 | 10 | 2 | 4 |
PR | 18 (78%) | 3 | 15 | 2 | 3 |
Her-2/neu | 20 (87%) | 8 | 12 | 2 | 1 |
EGFR | 18 (78%) | 3 | 15 | 5 | 0 |
CK 5/14 | 17 (77%) | 3 | 14 | 4 | 1 |
CK 18 | 14 (67%) | 14 | 0 | 7 | 0 |
Ki-67 (>25%) | 14 (61%) | 6 | 8 | 5 | 4 |
Skp 2 (>10%) | 15 (71%) | 0 | 15 | 5 | 1 |
