Figure 1

SNaPshot analysis of human seborrheic keratoses. (a) The R248C mutation was the most frequent FGFR3 mutation detected in this study (patient no. 55). (b) Normal epidermis adjacent to the seborrheic keratoses in patient no. 45 showed a wild-type FGFR3 status, confirming the somatic nature of FGFR3 mutations. (c) The seborrheic keratoses of patient no. 45 revealed a Y375C mutation.