Figure 3 | Modern Pathology

Figure 3

From: Validation of chromogenic in situ hybridization for detection of EGFR copy number amplification in nonsmall cell lung carcinoma

Figure 3

ROC curves derived from logistic regression analysis using CISH signal number to discriminate between FISH categories. (a) No EGFR amplification vs low polysomy. The open circle designates optimal CISH cut-off score of 2.8 with a sensitivity of 50% and specificity of 68%. (b) No EGFR amplification/low polysomy vs high polysomy/EGFR gene amplification. The open circle designates optimal CISH cut-off score of 4.5 with a sensitivity of 89% and specificity of 89%. (c) High polysomy vs EGFR gene amplification. The open circle designates optimal CISH cut-off score of 7.1 with a sensitivity of 78% and specificity of 81%.

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