Table 3 Loss of heterozygosity results in 17 myeloproliferative bone marrows

From: Loss of heterozygosity identifies genetic changes in chronic myeloid disorders, including myeloproliferative disorders, myelodysplastic syndromes and chronic myelomonocytic leukemia

 

D7S2554

D8S263

D9S157

D9S161

D13S319

TP53

D20S108

CASE 1 ET

 CON

       

 HP

    

 

 Mk

 

   

CASE 2 ET

 CON

       

 HP

+

 

+

+

  

+

 Mk

  

+

+

 

+

CASE 3 ET

 CON

      

N

 HP

 

+

+

 

+

 

N

 Mk

 

+

+

 

+

 

N

CASE 4 ET

 CON

       

 HP

    

  

 Mk

     

 

CASE 5 ET

 CON

N

      

 HP

N

 

+

+

   

 Mk

N

 

+

+

   

CASE 6 ET

 CON

       

 HP

 

+

     

 Mk

 

+

 

   

CASE 7 ET

 CON

       

 HP

   

+

 

 

 Mk

  

+

  

CASE 8 ET

 CON

    

N

  

 HP

+

   

N

 

 Mk

+

   

N

  

CASE 9 PV

 CON

N

N

   

N

 

 HP

N

N

 

 

N

+

 Mk

N

N

   

N

+

CASE 10 PV

 CON

  

N

 

N

  

 HP

  

N

N

+

 

 Mk

 

N

 

N

+

 

CASE 11 CIMF

 CON

       

 HP

    

+

  

 Mk

    

+

  

CASE 12 CIMF

 CON

       

 HP

+

     

 Mk

+

    

 

CASE 13 CIMF

 CON

N

 

N

    

 HP

N

 

N

+

  

+

 Mk

N

 

N

+

  

+

CASE 14 CIMF

 CON

    

N

  

 HP

 

+

+

 

N

  

 Mk

 

+

+

 

N

  

CASE 15 CIMF

 CON

       

 HP

   

+

 

+

 

 Mk

   

+

 

+

 

CASE 16 CIMF

 CON

 

N

    

N

 HP

+

N

 

+

 

N

 Mk

+

N

  

+

 

N

CASE 17 CIMF

 CON

       

 HP

 

+

     

 Mk

 

+

     
  1. CIMF, chronic idiopathic myelofibrosis; CML, chronic myelogenous leukemia; CON, non-hematopoietic normal tissue controls; ET, essential thrombocythemia; HP, non-megakaryocytic hematopoietic cells; Mk, megakaryocytes; PV, polycythemia vera.
  2. ‘+’ indicates presence of abnormal, homozygous signal (eg, loss of heterozygosity). ‘N’ indicates non-informative study. Gray ‘’ indicates clonal difference in megakaryocytic lineage, not seen in surrounding hematopoietic tissue. Bold ‘’ indicates clonal difference in non-megakaryocytic cells, not seen in corresponding megakaryocytic lineage.
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