Figure 4
Expression of PDGFR-α, PDGFR-β, PDGF-A, and PDGF-B in putative precursor lesions for ovarian clear-cell adenocarcinomas. Immunohistochemistry for PDGFR-α (a, e, i, and m), PDGFR-β (b, f, j, and n), PDGF-A (c, g, k, and o), and PDGF-B (d, h, l, and p) in clear-cell adenocarcinoma-associated endometriosis without cytologic atypia (a–d) and with cytologic atypia (e–h), clear-cell adenocarcinoma-associated clear-cell adenofibroma components without atypia (i–l), and with atypia (m–p). PDGFR-α, PDGFR-β, and PDGF-A are positive in the epithelial components of endometriosis without atypia (a–c) and with atypia (e, f–g), and in clear-cell adenofibroma with atypia (m–o). PDGF-B is positive in epithelial components of endometriosis without atypia (d) and clear-cell adenofibroma with atypia (p), but negative in endometriosis with atypia (h), and clear-cell adenofibroma without atypia (l). Immunoperoxidase staining, original magnification × 200.
