Figure 2
From: Podoplanin is a useful diagnostic marker for epithelioid hemangioendothelioma of the liver
Expression of podoplanin and CD34 in primary liver tumors. In epithelioid hemangioendothelioma, epithelioid tumor cells are diffusely positive for podoplanin and CD34. Podoplanin is mainly expressed on the cellular membrane (inset). The expression of podoplanin is intense in the area in which the expression of CD34 is weak (left lower area). In hemangioma, podoplanin is expressed in lymphatic vessels in the fibrous septa. CD34 is expressed in both lymphatic vessels and neoplastic endothelial cells. In angiosarcoma and angiomyolipoma, neoplastic endothelial cells are positive for CD34, although podoplanin expression is not observed (all images, × 100; inset, × 400; three images of epithelioid hemangioendothelioma in almost the same field).
