Figure 3 | Modern Pathology

Figure 3

From: Frequent accumulation of nuclear E-cadherin and alterations in the Wnt signaling pathway in esophageal squamous cell carcinomas

Figure 3

Increased E-cadherin stabilizes β-catenin in cells. E-cadherin and β-catenin levels were examined in HEK293 cells that stably express Ecad-2301 and Ecad-1904. Both E-cadherin constructs stabilized β-catenin levels in the cells (a). The constructed tissue microarray from esophageal tumors was stained with antibodies against E-cadherin and β-catenin. Within the same slide, we found variation in expression and subcellular localization of both markers (b). Tumors with high cytoplasmic levels of E-cadherin (panel 3) also showed increased β-catenin (panel 4). However, cells expressing nuclear E-cadherin (panel 5) mostly showed normal β-catenin distribution in esophagus tumors (panel 6) while cells with normal E-cadherin distribution showed normal β-catenin expression in these esophagus tumors (panels 1 and 2).

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